Cryostats used on a suspected CJD case should be decontaminated with what?

The appropriate choice for decontaminating cryostats used on suspected cases of Creutzfeldt-Jakob Disease (CJD) is sodium hydroxide. This substance is effective due to its strong alkaline properties, which can denature prion proteins associated with CJD. These prions are notoriously resistant to traditional disinfection methods and require a more aggressive approach for effective decontamination.

Sodium hydroxide works by altering the structure of the prion proteins, rendering them non-infectious. Its usage ensures that any contaminated surfaces are treated thoroughly, thus minimizing the risk of prion transmission. This is particularly critical in settings where biological samples are processed, as CJD is a transmissible spongiform encephalopathy, and the proper handling and decontamination protocols are essential to ensure safety for healthcare workers and the environment.

In contrast, other options like alcohol, water, and citric acid lack the necessary efficacy against prion proteins. While alcohol can disinfect many pathogens, it is ineffective against prions. Water does not provide any disinfectant properties, and citric acid, while useful for some microbial disinfection, does not possess the necessary strength to denature prions. This underscores why sodium hydroxide is the recommended decont